Cthrc1 kda

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August undefined, 2024

Web~Two bands of 25-30 kDa (SDS-PAGE) Purity: ≥90% (SDS-PAGE) Endotoxin Content: 0.01EU/μg purified protein (LAL test). Concentration: 0.1mg/ml after reconstitution. ... Collagen triple helix repeat containing-1 (CTHRC1) is a 30kDa glycosylated secretory protein containing a short collagen-like motif contributing to vascular remodeling by ... WebOct 26, 2024 · The function of collagen triple helix repeat containing 1 (CTHRC1) as an oncogene has been reported in a growing number of publications. ... Highly conserved from lower chordates to mammals, the CTHRC1 protein was identified as a 30 kDa secreted protein and was first verified to be a differentially expressed gene in balloon-injured rat …

Recombinant Human CTHRC1 His Protein - Novus Biologicals

WebApr 17, 2024 · CTHRC1 has four different isoforms with molecular weights of about 12.3 kDa to 27 kDa; the full-length of CTHRC1 accounts for both secreted and cellular CTHRC1 . Glycosylated protein CTHRC1 with a … WebCTHRC1 protein expression summary. Single band larger than predicted size in kDa (+20%) but partly supported by experimental and/or bioinformatic data. joules 20% off code

CTHRC1 Antibody (1G12) (H00115908-M05): Novus Biologicals

WebCthrc1 is a 30 kDa secreted protein that has the ability to inhibit collagen matrix synthesis. Cthrc1 is also glycosylated and retains a signal sequence … We recently identified collagen triple helix repeat containing-1 (Cthrc1) as a novel gene induced in adventitial fibroblasts after arterial injury. WebThe recombinant human CTHRC1 consists of 224 amino acids and has a predicted molecular mass of 24.5 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh CTHRC1 is approximately … WebCTHRC1 is highly expressed multiple human cancers, including pancreatic cancer where it plays a significant role in the progression and metastasis of the disease by regulating migration and adhesion of tumors cells. CTHRC1 overexpression can also be used as an independent prognostic marker in gastric cancer. joule revel seattle

Anti-CTHRC1 antibody (ab85739) Abcam

WebAll lanes : Anti-CTHRC1 antibody (ab264411) at 1/1000 dilution Lane 1 : UACC-62 whole cell lysate Lane 2 : MALME-62 whole cell lysate Lane 3 : SR whole cell lysate Lane 4 : NIH/3T3 (mouse embryo fibroblast cell line) whole cell lysate Lysates/proteins at 50 µg per lane. Developed using the ECL technique. Predicted band size: 26 kDa Exposure time: … WebImmunohistochemistry-Paraffin: CTHRC1 Antibody [NBP2-31797] - Staining of human pancreas shows low positivity in glandular cells as expected. Immunohistochemistry-Paraffin: CTHRC1 Antibody [NBP2-31797] - Staining of human placenta shows strong cytoplasmic positivity in trophoblastic cells. how to look down in sims 4WebAnti-CTHRC1 antibody [EPR22851-145] (ab256458) Research with confidence – consistent and reproducible results with every batch. Long-term and scalable supply – powered by recombinant technology for fast production. Success from the first experiment – confirmed specificity through extensive validation. Ethical standards compliant ... how to look enby

"WebWestern Blot: CTHRC1 Antibody (1G12) [H00115908-M05] - Analysis of CTHRC1 expression in transfected 293T cell line by CTHRC1 monoclonal antibody (M05), clone 1G12. Lane 1: CTHRC1 transfected lysatE (26.2 KDa). " - Cthrc1 kda

Cthrc1 kda

WebCTHRC1 is overexpressed in multiple human cancers, and its expression is associated with increased migration and metastasis, as well as decreased survival (1-3). CTHRC1 expression is regulated through TGF-β/Smad3 …

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WebMay 22, 2024 · Collagen triple helix repeat containing 1 (CTHRC1), a secreted ECM protein, is a 28-kDa evolutionarily conserved extracellular matrix glycoprotein, containing an NH2-terminal signaling peptide for extracellular secretion, a short collagen triple helix repeat of 36 amino acids, and a COOH-terminal globular domain . WebDec 23, 2004 · CTHRC1 is a secreted 28-kDa protein that is glycosylated and highly conserved from lower chordates to mammals. A short collagen motif with 12 Gly-X-Y repeats appears to be responsible for trimerization of the protein and this renders the molecule susceptible to cleavage by collagenase.

WebProteolytic processing may generate multiple CTHRC1 isoforms. There is the potential for an intracellular full-length 33 kDa, 245 aa form, plus extracellular isoforms that are 28 kDa (aa 33-245), 26 kDa (aa 49-245), 20 kDa (aa 98‑245) and 18 kDa and 16 kDa in size, the last two representing variants of the 20 kDa form with C-terminal processing. WebCTHRC1 (Collagen triple helix repeat-containing protein 1) is a 28-30 kDa, secreted glycoprotein that bears similarity to the C1q/TNF alpha -related family of proteins. It is expressed by disparate cell types, including renal epithelium, neurons, osteoblasts, and smooth muscle cells.

WebCTHRC1 is a secreted 30 kDa glycoprotein that is highly conserved among vertebrates. The protein contains a N-terminal hydrophobic signal peptide that directs CTHRC1 for secretion, a short collagen triple helix repeat (CTHR) domain consisting of 12 repeats of the Gly-X-Y motif [11], and a WebFeb 8, 2024 · Collagen triple helix repeat containing 1 (CTHRC1) is an extracellular matrix protein that regulates tumor invasion and modulates the tumor microenvironment. However, the association of CTHRC1 with the prognosis and tumor-infiltrating lymphocytes of KIRP and KIRC has not been reported.

WebAug 12, 2024 · CTHRC1 expresses mainly in adventitial fibroblasts and neointimal smooth muscle cells of balloon-injured vessels and promotes cell migration and tissue repair in response to injury. CTHRC1 plays a ...

Web30.5 kDa: Protein Length: Full Length of Mature Protein: Tag Info: ... CTHRC1 is transiently expressed in the arterial wall in response to injury where it may contribute to vascular remodeling by limiting collagen matrix deposition and promoting cell migration. PMID: 15618538; Aberrant expression of CTHRC1 is widely present in human solid ... joules aestheticsWebApr 15, 2002 · Hepatocellular carcinoma (HCC) Malignant behaviors microRNA-155-5p (miR-155-5p) Collagen triple helix repeat containing 1 (CTHRC1) GSK-3β-involved Wnt/β-catenin signaling; ... Osteosarcoma microRNA-338-3p Activator of 90 kDa heat shock protein ATPase homolog 1 Tumor suppressor Translational repression; 82. how to look evilWebCTHRC1 gene deletion leads to fatty liver (steatosis) formation in mice while others exhibited inactivation of the CTHRC1 gene also results in low bone mass. Description. CTHRC1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 234 amino acids (31-243 a.a) and having a molecular mass of 25.3kDa. ... how to look exoticWebFor the independent antibodies validation the evaluation is based on comparison of the staining of two (or more) independent antibodies directed towards independent epitopes on the protein. For all cases except the siRNA validation, an image representative of the antibody staining pattern is shown. joule rating meaningWebFeb 9, 2012 · Collagen Triple Helix Repeat Containing-1 (CTHRC1) and Nuclear factor (erythroid-derived 2)-like 3 ... expression level in colorectal tumours when compared with normal tissues [9-12]. CTHRC1 is a 30 kDa secreted protein that has the ability to inhibit collagen matrix synthesis. how to look fancyWebThe molecular weight of secreted CTHRC1 (30 kDa) appears to be larger than that of cellular CTHRC1 (26 kDa). CTHRC1 has four different isoforms with molecular weights of about 12.3 kDa to 27 kDa ... how to look fakeWebOct 11, 2024 · Collagen triple helix repeat containing-1 (CTHRC1) is a 28-kDa secreted protein reported to be involved in vascular remodeling, bone formation and morphogenesis. This study aimed to investigate the role of CTHRC1 in promoting the metastasis of EOC and to elucidate the underlying molecular mechanisms. joules abbotsford coat