Tead1
WebJul 1, 2024 · Abstract. Mitochondrial dysfunction occurs in most forms of heart failure. We have previously reported that Tead1, the transcriptional effector of Hippo pathway, is … WebJan 19, 2024 · The Hippo signaling effector, TEAD1 plays an essential role in cardiovascular development. However, a role for TEAD1 in postmitotic cardiomyocytes (CMs) remains …
Tead1
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WebImmunofluorescent analysis of TEAD1 in COLO205 cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C) incubated with TEAD1 polyclonal antibody (Product # PA5-106477) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 at a … WebNov 23, 2024 · TEAD1/4 were overexpressed in GC cell lines and primary GC tissues. Knockdown of TEAD1/4 induced a significant anticancer effect in vitro and in vivo. TEAD1 was confirmed to be a direct target of miR-377-3p and miR-4269, while TEAD4 was negatively regulated by miR-1343-3p and miR-4269. Among them, miR-4269 was the …
WebNov 11, 2024 · Introduction: We previously demonstrated that TEAD1, the transcriptional effector of the Hippo pathway, plays a critical non-redundant role in adult cardiomyocyte (CM) homeostasis and its loss-of-function (LOF) results in acute lethal dilated cardiomyopathy. However, the functional pathways regulated by TEAD1 in CMs remain … WebMar 9, 2024 · Silencing YAP1 and TEAD1 suppressed the EPHA3 protein and mRNA levels. In addition, we identified putative TEAD enhancers in the distal EPHA3 promoter, where …
WebJun 24, 2024 · Mitochondrial dysfunction occurs in most forms of heart failure. We have previously reported that Tead1, the transcriptional effector of Hippo pathway, is critical for maintaining adult cardiomyocyte function, and its deletion in adult heart results in lethal acute dilated cardiomyopathy. Growing lines of evidence indicate that Hippo pathway … WebMar 3, 2024 · These results suggest that TEAD1 binds primarily at active enhancers to regulate downstream target genes. Analysis of TEAD1 binding at FGFBP1, CYR61, …
WebJul 5, 2024 · TEAD1, TEAD3 and TEAD4 are the only proteins that are co-immunoprecipitated together with VGLL3, YAP and TAZ. Whereas YAP and TAZ share 18.6% of their binding partners, VGLL3 only shares ∼1% of the binding partners with those for YAP or TAZ. Moreover, we could only identify the phosphatase PPP2R1A as a …
WebPolyclonal Antibody for studying TEAD1. Cited in 6 publications. Validated for Western Blotting. Highly specific and rigorously validated in-house, TEAD1 Antibody (CST #8526) … lego technic dealsWebTEF-1 (t ranscription e nhancer f actor-1) is a member of a family of transcription factors that contain an evolutionarily conserved DNA binding domain (DBD), TEA/ATTS.TEF-1 was identified as a HeLa cell transcriptional activator that bound, via its TEA domain, to the GT-IIC and Sph enhancer elements. Comparison of various enhancers indicates that TEF-1 … lego technic excavator kitWebAddgene Alerts. Receive email alerts when new plasmids with this gene become available. Log in to subscribe to Addgene Alerts. Description TEA domain transcription factor 1. Also known as AA, NTEF-1, REF1, TCF-13, TCF13, TEAD-1, TEF-1. Species Homo sapiens. Entrez ID 7003. lego technic electric setsTranscriptional enhancer factor TEF-1 also known as TEA domain family member 1 (TEAD1) and transcription factor 13 (TCF-13) is a protein that in humans is encoded by the TEAD1 gene. TEAD1 was the first member of the TEAD family of transcription factors to be identified. See more All members of the TEAD family share a highly conserved DNA binding domain called the TEA domain. This DNA binding domain has a consensus DNA sequence 5’-CATTCCA/T-3’ that is called the MCAT element. The three … See more • Heart development (myocardium differentiation, • Skeletal muscle development (alpha-actin of skeletal muscles), ) • Smooth muscle development (alpha-actin of smooth muscles), See more TEAD proteins require cofactors to induce the transcription of target genes. TEAD1 interacts with all members of the SRC family of steroid receptor coactivators. In HeLa cells TEAD1 and SRC induce gene expression, TEAD1 interacts with PARP (Poly-ADP ribose … See more TEAD1 is expressed in various tissues including skeletal muscle, pancreas, placenta, lung, and heart. See more TEAD proteins are found in many organisms under different names, assuming different functions. For example, in Saccharomyces … See more Protein Kinase A (pKA) can phosphorylate TEAD1 at serine 102, after the TEA domain. This phosphorylation is needed for the transcriptional activation of the α MyHC gene. Protein Kinase C (pKC) phosphorylates TEAD1 on serine and threonine next to … See more Analysis of cancer transcriptome databases (www.ebi.ac.uk/gxa) showed that TEAD1 is dysregulated in several types of cancers. … See more lego technic education setWebDec 10, 2024 · Of the 4 members of the TEAD family, Tead1 (also known as transcriptional enhancer factor 1 [TEF‐1]) is the most abundant in the heart, is a transcriptional regulator … lego technic excavator power ashensWebProduct Details. Recombinant Human Transcriptional enhancer factor TEF-1 (TEAD1) is a full-length protein expressed in the yeast. It was fused with a 6xHis-tag at the N … lego technic drive shaftWebView mouse Tead1 Chr7:112278563-112505991 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression lego technic f1