WebJan 4, 2024 · Thiotepa During Pregnancy and Breastfeeding. Thiotepa is not recommended for use during pregnancy. It is harmful to a fetus. Men and women should talk to their doctors about using birth control during treatment with thiotepa. It is unknown if thiotepa passes into breast milk. Consult your doctor before breastfeeding. Additional Information WebUse Thiotepa suppresses cell growth and division and was introduced in 1953 for use in cancer chemotherapy to treat lymphoma and a vari-ety of solid and soft-tissue tumors. It was commonly used in cancer therapy until the early 1970s (only 3 kg of thiotepa was used in 1973). Although thiotepa has largely been replaced by the nitrogen mustards,
Thiotepa - Chemotherapy Drugs - Chemocare
WebThiotepa (INN), sold under the brand name Tepadina, is a medication used to treat cancer.. Thiotepa is an organophosphorus compound with the formula (C 2 H 4 N) 3 PS. It is an analog of N,N′,N′′-triethylenephosphoramide (TEPA), which contains tetrahedral phosphorus and is structurally akin to phosphate.It is manufactured by heating aziridine with … WebThiotepa is administered intramuscularly, intravenously and intrathecally; other parenteral routes (e.g., intratumoral injections) have also been used. It has been used as instillations in cases of urinary bladder carcinoma … the good dinosaur scooter
Thiotepa (Tepadina) Cancer information Cancer Research UK
WebThiotepa (N,N′,N″-triethylenethiophosphoramide, MW 189) is an older chemotherapeutic anticancer agent that acts by alkylating DNA and is prescribed for treating solid tumors and various leukemias often at high doses and in combination with other anticancer agents. Mass spectrometric methods were developed for characterizing the structure of thiotepa … WebApr 2, 2024 · Thiotepa is a cytotoxic agent of the polyfunctional type, related chemically and pharmacologically to nitrogen mustard. The radiomimetic action of thiotepa is believed to occur through the release ... INDICATIONS AND USAGE Thiotepa for Injection, USP has been tried with varying results in the palliation of a wide variety of neoplastic diseases. WebSep 6, 2024 · If thiotepa is used during pregnancy, or if pregnancy occurs during thiotepa therapy, the patient and partner should be apprised of the potential hazard to the fetus. Thiotepa is a polyfunctional alkylating agent, capable of cross-linking the DNA within a cell and changing its nature. The replication of the cell is, therefore, altered, and ... the good dinosaur scenery